Asked by Jamie Stuart on May 07, 2024
Verified
Which of the following most accurately describes how foreign substances can activate complement?
A) Antibodies can bind to foreign antigens and activate complement through the classical pathway.
B) Foreign substances can bind to spontaneously activated C3 and stabilize it.
C) Foreign proteins bind to C1 and activate it.
D) Foreign proteins are phagocytized by macrophages and directly activate complement.
E) Both "Antibodies can bind to foreign antigens and activate complement through the classical pathway" and "Foreign substances can bind to spontaneously activated C3 and stabilize it" are correct.
Complement
Group of serum proteins that stimulates phagocytosis and inflammation.
Classical Pathway
Part of the specific immune system for activation of complement.
C3
A protein component of the immune system's complement system, which enhances the ability of antibodies and phagocytic cells to clear pathogens from an organism.
- Discuss the role of complement in immunity, including its activation pathways and outcomes.
Verified Answer
KN
karthika naiduMay 10, 2024
Final Answer :
E
Explanation :
The classical pathway of complement activation is initiated when antibodies bind to foreign antigens, and the alternative pathway can be activated when foreign substances bind to and stabilize spontaneously activated C3.
Learning Objectives
- Discuss the role of complement in immunity, including its activation pathways and outcomes.