Persistent substance craving and use despite significant life disruption and risk of physical harm is most characteristic of

A) intoxication.
B) withdrawal.
C) substance use disorder.
D) a near-death experience.

Substance Use Disorder

A disorder characterized by continued substance craving and use despite significant life disruption and/or physical risk

Intoxication

A state of being impaired, disoriented, or excited by the effects of drugs or alcohol.

Withdrawal

The process of reducing or eliminating the use of a substance after prolonged dependency, often characterized by unpleasant symptoms.