Asked by Montrel Lockhart on Sep 24, 2024

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Esters and amides are most easily made by nucleophilic acyl substitution reactions on ________.

A) alcohols.
B) acid anhydrides.
C) carboxylates.
D) carboxylic acids.
E) acid chlorides.

Nucleophilic Acyl Substitution

A type of organic reaction where a nucleophile replaces a leaving group in an acyl compound, forming a new covalent bond.

Esters

Organic compounds derived from an acid where at least one -OH (hydroxyl) group is replaced by an -O- (alkoxy) group, known for their fruity smells.

Amides

Organic compounds containing a carbonyl group linked to a nitrogen atom from an amine, fundamental in the structure of proteins.

  • Comprehend the application of nucleophilic acyl substitution in forming esters and amides.
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Subham Agarwal4 days ago
Final Answer :
E
Explanation :
Acid chlorides are the most reactive acylating agent and therefore provide the most efficient route to the formation of esters and amides. Acid anhydrides and carboxylic acids can also be used, but they are less reactive due to their lower electrophilicity. Carboxylates and alcohols are not suitable substrates for nucleophilic acyl substitution reactions.