Asked by RAGHAV AGGARWAL on Sep 24, 2024

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Which compound would react most rapidly with sodium methoxide and heat?

A) pyridine
B) 2-chloropyridine
C) 3-chloropyridine
D) 4-chloropyridine

Sodium Methoxide

A chemical compound used as a strong base in organic synthesis, often for the deprotonation of weak acids.

Chloropyridine

Refers to pyridine molecules substituted with one or more chlorine atoms, used as intermediates in the synthesis of pesticides and drugs.

Pyridine

An aromatic heterocyclic compound with the formula C5H5N, featuring a ring structure similar to benzene but with one CH group replaced by a nitrogen atom.

  • Explain the influence of substituents on the reactivity of pyridine towards electrophilic and nucleophilic substitution.
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GT
Gabriela Trejo5 days ago
Final Answer :
B
Explanation :
The presence of a halogen on the pyridine ring increases the reactivity towards nucleophilic substitution reactions. Among the given options, 2-chloropyridine has the chlorine atom in closest proximity to the methoxide nucleophile, making it the most reactive towards the reaction.