Asked by Jacob Kling on May 09, 2024

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How does transplatin stop DNA replication?

A) Through its interaction with guanines in the DNA
B) By binding to the minor groove of DNA
C) By forcing a kink in the DNA that cannot be repaired
D) It doesn't; transplatin is not a useful anti-cancer drug.

Transplatin

A platinum-based compound similar to cisplatin but differs in the arrangement of its molecular structure, impacting its effectiveness and use in chemotherapy.

DNA Replication

The biological process of producing two identical replicas of DNA from one original DNA molecule, essential for cell division.

Guanines

One of the four main nucleobases found in the nucleic acids DNA and RNA, pairing with cytosine.

  • Understand the mechanisms of action of certain drugs, such as transplatin, in the context of DNA replication and cancer treatment.
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JH
Josiah HarrisonMay 09, 2024
Final Answer :
D
Explanation :
Transplatin, unlike its isomer cisplatin, does not effectively stop DNA replication because it does not form the same type of cross-links with DNA. This makes it much less useful as an anti-cancer drug compared to cisplatin.