In the workplace, sexual orientation and ablebodiedness are protected from discrimination by Title VII of the Civil Rights Act of 1964.

While the Civil Rights Act of 1964 does protect against discrimination based on race, color, religion, sex, and national origin, it does not explicitly protect against discrimination based on sexual orientation or ablebodiedness. However, some courts have interpreted the prohibition on sex discrimination to include discrimination based on an individual's sexual orientation or gender identity. The Americans with Disabilities Act (ADA) protects individuals with disabilities against discrimination in the workplace based on their disability status.