One problem with before and after assessment of a particular form of treatment is that it ignores the possibility of __________.

A) spontaneous improvement
B) drug interactions
C) clinician bias
D) unmatched samples

Spontaneous Improvement

The unexpected or sudden recovery or amelioration of a condition or symptoms without deliberate intervention.

Drug Interactions

The effects that may occur when the action of one drug is altered by the presence of another drug, food, or substance.

Clinician Bias

The predispositions or prejudices of healthcare providers that can affect clinical judgment and decision-making, potentially leading to unequal treatment of patients.