The family members of a patient newly diagnosed with schizophrenia state that they do not understand what has caused the illness. The nurse's response should be based on which models? (Select all that apply.)

A) Neurobiological
B) Environmental
C) Family theory
D) Genetic
E) Stress

Compelling evidence exists that schizophrenia is a neurologic disorder probably related to neurochemical abnormalities, neuroanatomical disruption of brain circuits, and genetic vulnerability. Stress and family disruption may contribute but are not considered etiologic factors. Environmental factors are not recognized as causative variables in schizophrenia.