Asked by Tanmay Gawali on Sep 27, 2024

The following compound has been found effective in treating pain and inflammation (J. Med. Chem. 2007, 4222) . Which sequence correctly ranks each carbonyl group in order of increasing reactivity toward nucleophilic addition? The following compound has been found effective in treating pain and inflammation (J. Med. Chem. 2007, 4222) . Which sequence correctly ranks each carbonyl group in order of increasing reactivity toward nucleophilic addition?   A)  1 < 2 < 3 B)  2 < 3 < 1 C)  3 < 1 < 2 D)  1 < 3 < 2

A) 1 < 2 < 3
B) 2 < 3 < 1
C) 3 < 1 < 2
D) 1 < 3 < 2

Nucleophilic Addition

A fundamental type of reaction in organic chemistry where a nucleophile forms a bond with an electrophile, typically resulting in the addition of the nucleophile to a carbon atom.

Carbonyl Group

A functional group composed of a carbon atom double-bonded to an oxygen atom (C=O), central to many organic reactions.

  • Compare the reactivity of different carbonyl groups towards nucleophilic addition.