Thousands of controlled experiments indicate that

A) many people have ESP.
B) ESP exists only in a few specially gifted people.
C) there is no reliable evidence that anyone possesses ESP.
D) it is impossible to conduct scientifically valid tests for ESP.

The statement "there is no reliable evidence that anyone possesses ESP" is supported by thousands of controlled experiments. Therefore, option C is the best choice. Options A and B are incorrect because there is no evidence to prove that ESP exists in any individual or a certain group of people. Option D is also incorrect because numerous scientifically valid tests have been conducted to investigate the existence of ESP.