What is the term for a progressive decrease in one's response to a drug with repeated use

A)  habituation 
B)  dependency 
C)  tolerance 
D)  withdrawal

Progressive Decrease

A continuous reduction or decline in quantity, size, or strength over time.

Response To A Drug

The specific reaction or set of reactions exhibited by an organism following administration of a drug, which can vary widely depending on the individual's genetic makeup, dose, and history of use.

Tolerance

The ability or willingness to tolerate the existence of opinions or behavior that one dislikes or disagrees with, or the body's reduced response to a substance after repeated use.