When people need to consume larger and larger doses of a drug to obtain the desired effect, they have developed_____ on/for the drug.

A) psychological dependence
B) tolerance
C) withdrawal
D) all of these are true

Tolerance occurs when an individual requires increasingly higher doses of a drug to achieve the same effect. This often occurs with chronic drug use and can be a sign of physical dependence, but does not necessarily indicate psychological dependence. Withdrawal refers to the physical and psychological symptoms that occur when a person stops using a drug they have become dependent on.