Asked by Vipul Chandra on Jul 12, 2024
Verified
Which of the following will result in removal of a benzyl ester protecting group?
A) acid hydrolysis only
B) decarbonylation only
C) catalytic hydrogenation only
D) both acid hydrolysis and decarbonylation
E) both catalytic hydrogenation and acid hydrolysis
Benzyl Ester
An ester compound where the alcohol part of the ester is derived from benzyl alcohol, often used in organic synthesis as protective groups or intermediates.
Protecting Group
A temporary functional group added to a molecule to protect a reactive site from undesirable reactions during synthesis.
- Assess the construction of amino acids and peptides subsequent to precise chemical methodologies.
Verified Answer
ZK
Zybrea KnightJul 18, 2024
Final Answer :
E
Explanation :
Benzyl ester protecting groups can be removed through both catalytic hydrogenation, which breaks the carbon-carbon bond between the benzyl group and the oxygen of the ester, and acid hydrolysis, which hydrolyzes the ester linkage.
Learning Objectives
- Assess the construction of amino acids and peptides subsequent to precise chemical methodologies.