Asked by Manav Josan on Sep 22, 2024

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A total of 1,500 pairs of adult twins,600 monozygotic and 900 dizygotic,were studied to estimate the concordance for a childhood cancer.In the 600 monozygotic twins,40 of the pairs were concordant for the disease,60 of the pairs were discordant for the disease,and neither twin had the disease in the remaining 500 pairs.In the 900 dizygotic twins,30 of the pairs were concordant for the disease,120 of the pairs were discordant for the disease,and neither twin had the disease in the remaining 750 pairs.What is the discordance rate,in dizygotic twins,of the disease in twin pairs with at least one affected member?

A) 0.1
B) 0.2
C) 0.6
D) 0.8
E) 1.5

Discordance Rate

refers to the proportion of pairs of subjects where one subject has a condition or characteristic and the other does not.

Monozygotic Twins

Twins sharing the same genetic makeup as a result of one fertilized egg dividing into two separate embryos.

Dizygotic Twins

Also known as fraternal twins, they are two offspring born from the same pregnancy and fertilized by separate eggs.

  • Acquire knowledge on the rates of concordance and discordance in the context of genetic investigations involving twins.
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Vivian Witjaksono1 day ago
Final Answer :
B
Explanation :
The discordance rate of the disease in twin pairs with at least one affected member among of dizygotic twins is 30,the number of pairs with concordant,divided by 150,30 plus 120,the total number of pairs with at least one affected member.The discordance rate equals 0.2.