Asked by Sabrina Willard on Apr 26, 2024
Verified
Bradykinin is a nonapeptide released by globulins in the blood in response to a wasp sting. Hydrolysis gives the following amino acids: 2 Arg, Gly, 2 Phe, 3 Pro, and Ser. Edman degradation gives phenylthiohydantoin of Arg. Cleavage with carboxypeptidase gives Arg. Partial hydrolysis gives the following di- and tripeptides: Phe-Ser, Pro-Gly-Phe, Pro-Pro, Ser-Pro-Phe, Phe-Arg, and Arg-Pro. What is the amino acid sequence of bradykinin?
Bradykinin
A peptide that causes blood vessels to dilate (enlarge), resulting in a drop in blood pressure and increased pain sensitivity.
Nonapeptide
A peptide consisting of nine amino acid residues.
Edman Degradation
A method of sequencing amino acids in a peptide by stepwise removal of one amino acid at a time from the amino end of the peptide.
- Outline the procedures involved in determining amino acid sequences from proteins and peptides.
Verified Answer
NS
Learning Objectives
- Outline the procedures involved in determining amino acid sequences from proteins and peptides.
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