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Asked by Meschna Louis on Sep 24, 2024

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Which of the following is the most reactive carboxylic acid derivative?

A) ester
B) anhydride
C) nitrile
D) acid chloride
E) amide

Acid Chloride

Organic compounds derived from carboxylic acids by replacing the hydroxyl group with a chlorine atom, making them highly reactive acylating agents.

Anhydride

A compound formed from another compound by the removal of a molecule of water; commonly associated with carboxylic acid anhydrides in organic chemistry.

Carboxylic Acid

An organic compound containing a carboxyl group (C(O)OH), known for its acidity due to the hydrogen atom's ability to dissociate from the carboxyl group.

  • Understand the reactivity trends and mechanisms of carboxylic acid derivatives in nucleophilic acyl substitutions.
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Verified Answer

JB
Jessica Bernik5 days ago
Final Answer :
D
Explanation :
Acid chlorides are the most reactive carboxylic acid derivative due to the presence of a highly polarized C-Cl bond, which makes the carbonyl carbon more electrophilic and susceptible to nucleophilic attack. Consequently, acid chlorides are often used as reactive intermediates in organic synthesis.

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